Electrostatics and flexibility drive membrane recognition and early penetration by the antimicrobial peptide dendrimer bH1.
نویسندگان
چکیده
Molecular dynamics simulations of the polycationic antimicrobial peptide dendrimer (Leu)8(DapLeu)4(DapPhe)2DapLys-NH2 binding to membranes suggest that electrostatic interactions with the polyanionic lipopolysaccharide (LPS) and conformational flexibility of the 2,3-diaminopropanoic acid (Dap) branching units drive its selective insertion into microbial membranes.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 78 شماره
صفحات -
تاریخ انتشار 2013