Electrostatics and flexibility drive membrane recognition and early penetration by the antimicrobial peptide dendrimer bH1.

نویسندگان

  • Harish K Ravi
  • Michaela Stach
  • Thereza A Soares
  • Tamis Darbre
  • Jean-Louis Reymond
  • Michele Cascella
چکیده

Molecular dynamics simulations of the polycationic antimicrobial peptide dendrimer (Leu)8(DapLeu)4(DapPhe)2DapLys-NH2 binding to membranes suggest that electrostatic interactions with the polyanionic lipopolysaccharide (LPS) and conformational flexibility of the 2,3-diaminopropanoic acid (Dap) branching units drive its selective insertion into microbial membranes.

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عنوان ژورنال:
  • Chemical communications

دوره 49 78  شماره 

صفحات  -

تاریخ انتشار 2013